2024 Tongji Summer School Application Form
（For Individuals from outside of HUST）

【基本信息】

1. 授课教师：Nancy R Reynolds（美国约翰斯·霍普金斯大学）

2. 授课形式：远程教学

3. 学时：15

4. 适合学生：对全球健康问题、改善医疗保健的可及性和提高全民医疗水平感兴趣的学生。

5. 课程考核：无硬性作业和考试要求，但有推荐阅读、自我评价、互动问答、游戏活动。

【Basic Information】

1. Teacher: Nancy R Reynolds (Johns Hopkins University, USA)

2. Form of teaching: Remote Teaching

3. Class hour: 15

4. Oriented students: This course is designed for students interested in global health issues and improved access to health care and better health care for all.

5. Assessment: Suggested readings, self-evaluation with interactive quizzes and game-based activities.

【课程简介】

这门综合课程深入探讨了全球健康的动态性和复杂性，探索影响不同人群健康状况多方面的挑战和机遇。通过一系列教学板块，学生将深入了解全球健康的定义和范围、健康的决定因素，以及干扰全球健康进展的各种复杂性挑战。

主题包括：全球健康概述，包括其定义和范围；全球健康关键问题与挑战研究；健康公平与健康决定因素探讨；全球健康治理与资助；传染病分析，包括流行病学预防和控制策略；人口老龄化和非传染性疾病负担调查，包括风险因素和干预策略；全球心理健康问题概述；母婴健康，包括挑战和干预措施；环境健康问题，如气候变化、环境污染对健康的影响；冲突和移民对健康的影响；健康公平性及其面临的挑战；医疗卫生人员的分配与迁移；数字健康、创新和人工智能(AI)技术在全球健康变革中的作用；全球健康合作伙伴关系中的公平原则和策略。课程的授课形式主要包括专题讲座、案例分析、讨论和互动练习等，学生将参与讨论并对课程内容进行批判性分析。

【Course Introduction】

This comprehensive course delves into the dynamic and complex world of global health, exploring the multifaceted challenges and opportunities that define health outcomes across diverse populations. Through a series of modules, students will gain a deep understanding of the definition and scope of global health, the determinants of health, and a variety of interconnected complexities and challenges that are disrupting progress in health around the globe.

Topics include: Overview of global health, including its definition and scope; Examination of key global health issues and challenges; Discussion of health equity and the determinants of health; Exploration of global health governance and funding; Analysis of infectious diseases, including epidemiology, prevention, and control strategies; Investigation of the burden of aging populations and non-communicable diseases, including risk factors and intervention strategies; Overview of global mental health challenges; Examination of maternal and child health, including challenges and interventions; Discussion of environmental health issues, such as climate change, pollution, and their health impacts; Exploration of the health implications of conflicts and migration; Analysis of equitable access to health care and the challenges faced in achieving it; Examination of the healthcare workforce and issues related to its distribution and migration; Exploration of digital health, innovation, and the role of artificial intelligence (AI) technology in transforming global health; Discussion of the principles of equity in global health partnerships and strategies to ensure fair collaboration. Course will include guest lectures, case studies, discussion and interactive exercises. Throughout the course, students will participate in discussions and critically analyze course content. 

【教师简介】

Nancy R Reynolds教授是约翰斯·霍普金斯大学护理学院分管全球事务副院长、全球倡议中心主任、世界卫生组织（WHO）护理信息、知识和管理合作中心主任、世界卫生组织全球护理和助产实践社区指导委员会成员、世界卫生组织护理和助产合作中心前秘书长、世界卫生组织首届全球护理状况报告指导委员会成员、全球健康大学联盟（CUGH）副主席。Nancy教授连续25年获得美国国立卫生研究院（NIH）资助，支持针对加强美国和国际受艾滋病影响弱势群体的行为保健服务的研究。她于2018年入选由Sigma Theta Tau国际护理荣誉学会颁授的国际护理研究学者名人堂，同时还是美国护理科学院院士。

【Teacher Introduction】

NANCY R REYNOLDS, PhD, RN, FAAN, is a professor and the Associate Dean of Global Affairs at the Johns Hopkins University School of Nursing.  She is the Director of the Center for Global Initiatives; Director, WHO Collaborating Centre for Nursing Information, Knowledge and Management; Vice Chair of the Consortium of Universities in Global Health (CUGH) and co-Chair of the CUGH Workforce Capacity Building Committee. She is a member of the Steering Committee for the WHO Global Community of Practice for Nursing and Midwifery. She is the former Secretary General of Global Network of the WHO Collaborating Centers of Nursing and Midwifery and was a member of the Steering Committee of the inaugural WHO State of the World’s Nursing Report.  She has over 25 years of continuous NIH funding supporting research focused on enhancing behavioral health care services to vulnerable populations affected by HIV domestically and internationally. She is a Johns Hopkins School of Nursing Isabel Hampton Robb Scholar and was inducted in the Sigma International Nurse Researcher Hall of Fame in 2018. She is a Fellow in the American Academy of Nursing.

【基本信息】

1. 授课教师：Koh Woon Puay（新加坡国立大学）

2. 授课形式：现场教学

3. 学时：15

4. 适合学生：课程适合医学相关专业研究生及博士生参与（本科生也可以参与）；需具备流行病学方面的基础知识，以及一定的英文水平。

5. 课程考核：课程结束时不设考试，但通过本课程需要参加授课和讨论。

【Basic Information】

1. Teacher: Koh Woon Puay (National University of Singapore)

2. Form of teaching: In-Person Teaching

3. Class hour: 15

4. Oriented students: Currently enrolled in a research programme in epidemiology (can be Basic, Master or PhD). As this programme is taught in English, a certain level of English proficiency is expected.

5. Assessment: There is no examination in the end of the course, participation in lectures and discussion sessions is required to pass the course.

【课程简介】

研究成果需要通过发表来传播。学习写一篇好的科学论文，类似于写一个好的故事——重要的不仅是内容，更是讲述故事的方式，即对数据的表述和解释，决定了一篇科学论文的成功。本课程将利用文献中的实际案例，讲授撰写好一篇科学论文的道德规范、一般原则和技巧。并将有机会进行写作练习并接受点评。

本课程的重点是流行病学研究领域的出版物的表达及写作风格。主题包括：出版中的道德规范，句子的结构和词语的选择，撰写导言、方法、结果和讨论的指南，以及对审稿人意见的回应。

课程将计划设置一个对参与者写作内容进行点评的环节，以帮助参与者提高自身写作能力。

【Course Introduction】

Research output needs to be disseminated via publication. Learning to write a good scientific paper is akin to writing a good story – it is not only the content, i.e. the data, that matters, but the way the story is told, i.e. the presentation and interpretation of data, that determines the success of a scientific paper. In this course, the ethics, general principles and tips in writing a good scientific paper will be taught, using practical examples from the literature. There will also be a chance to practise writing and to receive critique.

This writing workshop focuses on the presentation and style of publications in epidemiologic research. Topics include: ethics in publication, construction of sentences and choice of words, guidelines to writing the introduction, methods, results and discussion, and responding to reviewers' comments.

There is a planned session to receive critique for one's writing.

【教师简介】

Koh Woon-Puay 是新加坡国立大学杨潞龄医学院教授，院长助理。Koh教授在新加坡国立大学获得MBBS（荣誉）学位，在澳大利亚悉尼大学获得免疫学博士学位，并在美国南加州大学接受博士后培训。作为流行病学专家，Koh教授研究重点为基因、饮食和生活方式因素在慢性疾病和衰老结果流行病学中的作用。Koh教授的研究内容结合了她在临床医学方面的知识和实验室科学培训以及流行病学方法，以揭示疾病发病机制途径。Koh教授目前担任新加坡华族健康研究的首席研究员，发表关于饮食、生活方式和基因与疾病风险相关的科学论文450余篇。

【Teacher Introduction】

Koh Woon-Puay is Professor at Healthy Longevity Translational Research Programme, Yong Loo Lin School of Medicine at the National University of Singapore. She received her MBBS (Honours) from NUS, her PhD in Immunology from the University of Sydney, Australia, and postdoctoral training in University of Southern California in USA. As an epidemiologist, she is interested in the roles of genes, diet and lifestyle factors in the epidemiology of chronic diseases and ageing outcomes. Her research incorporates her knowledge in clinical medicine and training in laboratory science with epidemiologic methods to unravel putative mechanistic pathways in disease aetiology. She is the Principal Investigator of the Singapore Chinese Health Study, a 63,257-strong cohort of middle-aged and elderly Chinese Singaporeans established for the long-term study of dietary and environmental determinants of chronic diseases common among Singaporeans. Professor Koh has co-authored over 450 scientific papers on diet, lifestyle and genes in relation to risk of diseases such as cancer, cardiovascular diseases, diabetes, gout, osteoporosis, osteoarthritis, tuberculosis disease, cognitive impairment and physical frailty in ageing. Besides research, her other passion is in mentoring, and in her capacity as Assistant Dean for Faculty Development, she leads efforts in developing young faculty and clinician-scientists in their research careers.

【基本信息】

1. 授课教师：袁长征（中国浙江大学）

2. 授课形式：远程教学

3. 学时：16

4. 课程考核：总成绩：平时签到25%，课堂讨论或者课后习题25%，小组汇报50%。

【Basic Information】

1. Teacher: YUAN Changzheng (Zhejiang University, China) 

2. Form of teaching: Remote Teaching

3. Class hour: 16

4. Assessment: Grading Breakdown: 25% Attendance, 25% Class Discussions/Homework, 50% Group Presentations.

【课程简介】

营养流行病学是营养学与流行病学的交叉学科，是探索人群膳食营养状况，研究膳食营养与疾病和健康关联的重要学科。目前国内外大型人群研究中越来越重视膳食营养信息的收集与分析，因此了解和掌握营养流行病学的原理、方法和实践技能尤为重要。本课程将围绕膳食营养评估方法、信效度研究、总能量校正、常见研究设计及分析方法，让学生系统性地了解营养流行病学，获得膳食评估、分析和解释膳食摄入数据的理论和实践经验，以及进行营养流行病学研究设计来研究膳食与疾病之间的关系的基本能力。

【Course Introduction】

Nutritional epidemiology is the study of dietary assessment, dietary determinants of health-related states or events in specified populations, and the public health application of this research. Research investigating diet-disease relationships has received growing interest in population-based studies worldwide. This course introduces students to the key concepts, methods and practical skills of nutritional epidemiology, including methods for dietary assessment, dietary validation studies, methods for adjustment for total energy intake, study design, data analysis and interpretation. Students will learn how to apply these methods and practical skills to interpret the nutritional epidemiology literature and design the studies of their interest.

【教师简介】

袁长征博士，浙江大学公共卫生学院百人计划研究员，博士生导师，哈佛大学陈曾熙公共卫生学院兼职助理教授。曾获北京大学公共卫生学院预防医学学位以及经济学双学位，哈佛大学公共卫生学院流行病方法学硕士及营养流行病学博士学位。从事营养流行病学方面的研究工作，在膳食测量、营养与健康等领域开展了一系列人群实证研究。在Nature Aging、Nature Food、American Journal of Epidemiology、American Journal of Clinical Nutrition、Alzheimer's & Dementia、Neurology、JAMA Pediatrics等国际权威期刊发表100余篇文章。当前研究主要聚焦营养与老年认知衰退的人群研究及相关内稳态及免疫衰老机制研究。

【Teacher Introduction】

Nutritional epidemiology is the study of dietary assessment, dietary determinants of health-related states or events in specified populations, and the public health application of this research. Research investigating diet-disease relationships has received growing interest in population-based studies worldwide. This course introduces students to the key concepts, methods and practical skills of nutritional epidemiology, including methods for dietary assessment, dietary validation studies, methods for adjustment for total energy intake, study design, data analysis and interpretation. Students will learn how to apply these methods and practical skills to interpret the nutritional epidemiology literature and design the studies of their interest.

【基本信息】

1. 授课教师：Oscar H. Franco，Vicente Artola（荷兰乌得勒支大学）

2. 授课形式：远程授课

3. 学时：16

【Basic Information】

1. Teacher: Oscar H. Franco，Vicente Artola (Utrecht University, The Netherlands)

2. Form of teaching: Remote Teaching

3. Class hour: 16

【课程简介】

临床流行病学的研究问题源于临床实践，直面患者的医护人员常面临如下的问题：患病机制是什么？（病因学），为什么会患病？（危险因素），如何避免患病？（预防），什么类型的疾病？（诊断），患病后有什么后果？（预后），患病后应该注意些什么？（治疗）。为了解决这些问题，有以下几种研究设计，包括队列研究，病例对照研究，随机对照临床试验。临床流行病学研究的结果将为临床决策提供证据。

在本次课程中，将通过已发表研究成果或正在进行中的研究实例来理解临床流行病学原理和实践，通过示例讲解如何通过研究设计来解决临床实践中的问题。

课程主题包括：应用临床研究的原理；病因学研究；疾病危险因素；预测、预后、预防研究、系统评价和Meta分析。

【Course Introduction】

Research questions in clinical epidemiology originate from direct clinical practice. Healthcare professionals in contact with patients often encounter questions that involve what caused the disease？ (Etiology), why did I get it? (Risk factors), Could I have done something to avoid it? (Prevention), what type of disease do I have? (Diagnosis), what would happen to me now that I have this disease? (Prognosis) and/or what can I do about it? (Therapy).

To answer these questions, several study designs are available, ranging from cohort and case-control studies to randomized controlled clinical trials. Results from clinical epidemiological research are used in patient management decisions.

In this course, the principles and practice of clinical epidemiology will be considered, using practical examples from the literature and from ongoing studies. We will evaluate basic concepts as well as in depth examples on how we can derive questions formulated in the practice into research studies and programs.

【教师简介】

Oscar H. Franco博士，瑞士伯尔尼大学流行病学和公共卫生学教授、伯尔尼大学社会医学和预防医学研究所 (ISPM) 所长，哈佛大学公共卫生学院的兼职教授。发表论文700余篇，H指数为94。Franco博士曾担任剑桥大学公共卫生临床讲师。2012年担任伊拉斯姆斯大学医学中心预防医学系教授和心血管流行病学组首席研究员,创建并指导了鹿特丹代际老龄化研究中心(the Rotterdam Intergenerational Ageing Research Center)，并担任Erasmus Epidemiology Resources的共同创始人和CEO。Franco博士是欧洲心脏病学会 (ESC) 会士，剑桥大学圣埃德蒙学院研究员。2005年被授予荷兰国家公共卫生奖。

Vicente Artola Arita是荷兰乌特勒支大学全球公共卫生与生物伦理学系的助理教授，萨尔瓦多大学公共卫生学院客座教授。Artola教授于2012年在萨尔瓦多大学获得医学博士学位。2015年，在萨尔瓦多安德烈斯大学获得卫生管理硕士学位，2017年，在西班牙胡安卡洛斯国王大学获得人类免疫缺陷病毒学硕士学位。2014年至2018年，Artola教授于萨尔瓦多国家卫生研究所和萨尔瓦多社会保障研究所担任研究员。2018年，Artola教授于荷兰格罗宁根大学医学中心攻读心血管疾病博士学位，研究重点是利用超声心动图参数和生物标志物研究房颤、心衰和性别差异。目前主要研究方向是心脏代谢性疾病、生活方式的干预和人口层面的健康决定因素。

【Teacher Introduction】

Prof. Oscar H. Franco is Professor of Epidemiology and Public Health and Director of the Institute of Social and Preventive Medicine (ISPM) at the University of Bern. Furthermore, he is Adjunct Professor at the Harvard T.H. Chan School of Public Health. He has published over 700 publications and has a H-index of 94. He was previously a clinical lecturer in public health at the University of Cambridge. In 2012, he worked as professor of preventive medicine and the principal investigator of the cardiovascular epidemiology group in ErasmusMC. He also founded and directed the Rotterdam Intergenerational Ageing Research Center, ErasmusAGE, and he was cofounder and CEO of Erasmus Epidemiology Resources.A fellow of, inter alia, the European Society of Cardiology and St Edmunds’ College at the University of Cambridge, Prof. Franco was awarded the Dutch national public health prize of 2005.

Vicente Artola Arita is an Assistant Professor at the Department of Global Public Health & Bioethics, UMC Utrecht, The Netherlands. Vicente is also a Guest Professor at the School of Public Health, University of El Salvador, Central America and scientific advisor for the French television channel France24 and the National Institute of Health, El Salvador. Vicente Artola Arita obtained his MD at Universidad de El Salvador, El Salvador in 2012. In 2015, he obtained his MSc in Health Administration at Universidad Andrés, El Salvador and in 2017, his MSc in Human Immunodeficiency Virus at Universidad Rey Juan Carlos, Spain. In 2019, he obtained his Doctorate Degree in Research and Teaching from Universidad Centro Panamericano de Estudios Superiores, Mexico. Between 2014 and 2018, he worked as a researcher and facilitator of research designs and ethics in governmental institutions in El Salvador, the National Institute of Health and the Salvadoran Institute of Social Security. In 2018, he moved to the Netherlands to pursue his PhD at the University Medical Center Groningen in cardiovascular diseases, focusing on atrial fibrillation, heart failure and sex differences using echocardiographic parameters and biomarkers. During his PhD he obtained the prize of best thesis project pitch in the 3-minute thesis competition in the Netherlands.His work focuses now on cardiometabolic diseases, lifestyle interventions and determinants of health at the population level.

【基本信息】

1. 授课教师：周翔（美国密歇根大学）

2. 授课形式：远程授课

3. 学时：15

【Basic Information】

1. Teacher: ZHOU Xiang (University of Michigan, USA)

2. Form of teaching: Remote Teaching

3. Class hour: 15

【课程简介】

这门课程深入探讨了应用于多种大规模基因组数据集的最前沿统计学和计算方法及工具，重点聚焦于全基因组关联研究（GWAS）、RNA测序研究、空间转录组学以及综合分析技术。

课程将涵盖GWAS研究设计、数据结构、常见分析方法、群体结构及个体相关性调整、多效性映射与多重相关性状建模、因果关联的精细定位、遗传力与遗传相关性分析、多基因风险评分分析；差异基因表达分析，表达量性状位点（eQTL）映射；空间转录组学介绍，空间变异基因检测，细胞类型去卷积，组织分割与功能域检测；全转录组关联研究，整合分析中的孟德尔随机化，以及全转录组关联研究中的精细映射等内容。

通过讲座，学生将接触到真实世界的应用，并学习分析和解释基因组数据的技能，重点在于解决复杂的生物学问题，揭示人类特质和疾病遗传基础的见解。

【Course Introduction】

This course provides an in-depth exploration ofstate-of-art statistical and computational methods and tools applied to various large scale genomic datasets, focusing on genome-wide association studies (GWAS), RNA sequencing studies, spatial transcriptomics, and integrative analysis techniques. The course will provide an overview of GWAS study design, data structure, common analysis approaches, adjustment of population structure and individual relatedness, pleiotropic mapping and modeling of multiple correlated traits, fine-mapping of causal associations, heritability and genetic correlation analysis, polygenic risk score analysis; differential gene expression analysis, expression quantitative trait loci (eQTL) mapping; introduction to spatial transcriptomics, detection of spatially variable genes, cell type deconvolution, tissue segmentation and functional domain detection; transcriptome-wide association studies, Mendelian randomization for integrative analysis, and fine-mapping in transcriptome-wide association studies. Through lectures, students will gain exposure to real-world applications and learn skills in analyzing and interpreting genomic data, with a focus on addressing complex biological questions and uncovering insights into the genetic basis of human traits and diseases.

【教师简介】

周翔，密歇根大学公共卫生学院生物统计系教授，精准医学中心助理主任。长期从事统计遗传与基因组学研究，在统计模型和计算方法等方面取得一系列创新成果。获北京大学生物学学士、杜克大学统计学硕士和神经生物学博士学位。曾任教于芝加哥大学统计系，荣获William H. Kruskal Instructorship，John G. Searle Assistant Professorship，Mid-career Biosciences Faculty Achievement Recognition Award (MBioFAR)等多个奖项。发表通讯作者论文70余篇，包括Nature Biotechnology, Nature Genetics, Nature Methods。目前担任美国统计协会（ASA）遗传与基因组统计学分会（SSGG）的项目主席，《Annals of Applied Statistics》和《PLOS Genetics》等多部杂志常任副主编，以及《Genome Biology》特刊副主编。

【Teacher Introduction】

Xiang Zhou is a professor in the Department of Biostatistics at the University of Michigan School of Public Health and an associate director at the Center for Precision Health Data Science. He has dedicated his career to research in statistical genetics and genomics, achieving a series of innovative results in statistical models and computational methods. Zhou earned a Bachelor of Science in biology from Peking University, a Master's degree in statistics, and a Ph.D. in neurobiology from Duke University. He previously taught at the University of Chicago's Department of Statistics, where he was honored with the William H. Kruskal Instructorship, John G. Searle Assistant Professorship, and Mid-career Biosciences Faculty Achievement Recognition Award (MBioFAR), among other accolades. He has published over 70 papers as a corresponding author in prestigious journals such as Nature Biotechnology, Nature Genetics, and Nature Methods. Currently, he serves as the program chair for the Statistical Society for Genetics and Genomics (SSGG), a section of the American Statistical Association (ASA). Additionally, he is a standing associate editor for multiple journals including The Annals of Applied Statistics and PLOS Genetics, as well as a guest associate editor for a special issue of Genome Biology.

【基本信息】

1. 授课教师：Sara Hägg（瑞典卡罗林斯卡学院）

2. 授课形式：远程授课

3. 学时：16

4. 课程考核：课程结束时不设考试，但通过本课程需要参加授课和讨论会。

【Basic Introduction】

1. Teacher: Sara Hägg (Karolinska Institutet, Sweden)

2. Form of teaching: Remote Teaching

3. Class hour: 16

4. Assessment: There is no examination in the end of the course, participation in lectures and discussion sessions is required to pass the course.

【课程简介】

在为期五天的课程中，我们将重点学习遗传学和分子流行病学研究的基本概念、方法和研究设计。本课程将融合多种学习形式，包括zoom线上授课、阅读课程、视频材料和讨论。课程结束时不设考试，但通过本课程需要参加讲座和讨论会。

本课程的预期学习效果如下所示。成功完成本课程后，您将能够：

•  描述人类基因组的基本组织、家族遗传，以及遗传变异如何影响复杂性状。

•  解释具体的遗传学方法，以及如何在流行病学研究中使用这些方法。

•  解释不同类型的分子组学技术，以及如何在流行病学研究中使用这些方法。

•  描述基于人群的队列研究设计的基本原理。

•  举例说明遗传方法如何对研究和个人有益。

【Course Introduction】

This is a five-day course that focuses on basic concepts, methods and study design in genetic and molecular epidemiology research. The course will be given in a blended learning format, consisting of lectures on zoom, reading sessions, video material and discussions. There is no examination in the end of the course, participation in lectures and discussion sessions is required to pass the course.

The intended learning outcome of the course is listed below. After successfully completing this course you are expected to be able to:

- Describe the basic organization of the human genome, familial inheritance, and how genetic variation can influence complex traits.

- Explain specific genetic methods and how these methods can be used in epidemiological studies.

- Explain different types of molecular omics techniques and how these methods can be used in epidemiological studies.

- Describe the fundamentals of study design of population-based cohorts.

- Give examples of how genetic methods can be beneficial for research and for individuals.

【教师简介】

Sara Hägg博士，瑞典卡罗林斯卡学院医学流行病学和生物统计学系首席研究员，分子流行病学副教授(docent)。Sara 教授在斯德哥尔摩大学获得计算机科学理学学士和分子生物学理学硕士学位，并于2009年在瑞典林雪平大学获得计算生物学博士学位。自2015年以来，Sara 教授专注于衰老分子流行病学研究。2016年于斯坦福大学担任客座助理教授。Sara 教授正在与斯德哥尔摩地区医院的老年医师合作，研究老年患者的衰弱与新冠肺炎情况，并正在与华中科技大学的王齐教授及其团队合作，研究新冠疫情如何影响武汉和斯德哥尔摩老年人健康状况。

【Teacher Introduction】

Sara Hägg, PhD, is a Principal Researcher at the Department of Medical Epidemiology and Biostatistics at Karolinska Institutet (KI) in Stockholm, Sweden, where she is also a Docent in Molecular Epidemiology (Swedish teaching qualification degree). She did her undergraduate training at Stockholm University majoring in Molecular Biology (MSc) and Computer Science (BSc) and completed her thesis in Computational Biology (PhD) at Linköping University, Sweden, in 2009. Since 2015, Dr. Hägg has focused on molecular epidemiological studies of aging. In 2016, she was a visiting assistant professor at Stanford University. She is working with geriatricians from hospitals in the Stockholm area studying frailty and covid-19 in the old patients. She also collaborates with Professor Qi WANG and colleagues at the Huazhong University of Science and Technology, studying how the pandemic has affected the health of the older population in Wuhan and Stockholm.

【基本信息】

1. 授课教师：战义强（中国中山大学）

2. 授课形式：现场教学

3. 学时：16

4. 课程考核：课程结束时不设考试，但通过本课程需要参加授课和讨论会。

【Basic Information】

1. Teacher: ZHAN Yiqiang (Sun Yat-sen University, China)

2. Form of teaching: In-person Teaching

3. Class hour: 16

4. Assessment:  There is no examination in the end of the course, participation in lectures and discussion sessions is required to pass the course.

【课程简介】

在本课程中，我们将从回顾流行病学的概念和目标及其与因果推断的关系开始，然后进一步探讨遗传学如何帮助学习流行病学中的因果关系。我们将关注孟德尔随机化法（MR），它使用遗传变异作为工具变量来检验或估计（非遗传）风险因素对疾病或健康相关结局的潜在因果作用。当这些假设得到满足时，MR方法可以克服从观察性流行病学研究中得出的关联的局限性，并帮助确定药物干预和公共卫生干预的潜在目标的优先级。这门短期课程将首先带领大家理解MR背后因果推理的基本原理；其次进行一项MR研究，涵盖单样本和双样本孟德尔随机框架内因果推理的简单和复杂统计方法。该课程也会在MR框架的比较中进一步讨论一些话题，例如遗传风险评分分析、LD评分回归、倾向评分分析。

【Course Introduction】

In this course, we will start from reviewing the concepts and aims of epidemiology and its relationship with causal inference, then we move further on how genetics can help to learn causality in epidemiology. We will focus on Mendelian randomization (MR), which uses genetic variants as instrumental variables to test or estimate the potential causal effect of a (non-genetic) risk factor on a disease or health-related outcome. When the assumptions are met, the MR approach can overcome the limitations of associations drawn from observational epidemiology and help prioritizing potential targets for pharmaceutical and public health interventions. This short course will provide all the tools necessary first to understand the basic principles of causal inference underlying MR and second to perform an MR study, covering both simple and complex statistical methods for causal inference within one- and two- sample Mendelian randomization frameworks. Further topics, such as genetic risk score analysis, LD score regression, propensity score analysis will also be discussed in comparisons with the MR framework.

【教师简介】

战义强，中山大学公共卫生学院（深圳）流行病与卫生统计学副教授、博士生导师，广东省珠江人才计划青年拔尖人才。本科毕业于山东大学预防医学专业，硕士毕业于复旦大学流行病与卫生统计学专业，博士毕业于瑞典卡罗琳斯卡医学院流行病学专业。先后在瑞典卡罗琳斯卡医学院从事博士后研究工作，2020年起担任德国亥姆霍兹国家研究中心联合会-德国神经退行性疾病研究中心(DZNE)神经流行病学课题组组长、博士生导师，2021年起担任瑞典卡罗琳斯卡医学院助理教授、博士生导师。主要从事老年流行病学、神经流行病学、心血管糖尿病等代谢性疾病、慢性阻塞性肺病等的慢性非传染性疾病等流行病学研究工作。

【Teacher Introduction】

Dr. Yiqiang Zhan is an Associate Professor of Epidemiology at the School of Public Health (Shenzhen), Sun Yat-Sen University, Shenzhen, China. Before moving to Shenzhen, he was a tenure-track Assistant Professor in epidemiology at Karolinska Institutet, Sweden. He was also a group leader and principal investigator in neuroepidemiology at the German Center for Neurodegenerative Diseases (DZNE). Dr. Zhan has been working on aging and neurodegenerative diseases for the past years and was awarded the NIA Telomere Research Network Award in 2021. He obtained his bachelor, master, and Ph.D. degrees from Shandong University, Fudan University, and Karolinska Institutet, respectively. He has published over 70 articles and has a H-index of 24.

【基本信息】

1. 授课教师：Frank Elsner (德国亚琛工业大学)，Piret Paal（奥地利萨尔茨堡帕拉塞尔苏斯医科大学）

2. 授课形式：现场授课

3. 学时：15

【Basic Information】

1. Teacher: Frank Elsner (RWTH Aachen University, Germany), Piret Paal (Paracelsus Medical University in Salzburg, Austria)

2. Form of teaching: In-Person Teaching

3. Class hour: 15

【课程简介】

1. 疼痛与症状管理（3 小时）

2. 沟通技巧（3 小时）

3. 生命末期的伦理与决策（3 小时）

4. 精神关怀、悲伤和丧亲之痛（3 小时）

5. 处理姑息关怀： 它对您意味着什么？公开讨论（3 小时）

【Course Introduction】

1. Pain and Symptom Management (3h)

2. Communication Skills (3h)

3. Ethics and Decision Making at the End of Life (3h)

4. Spiritual Care, Grief and Bereavement (3h)

5. Dealing with Palliative Care: What does it mean to you? An open discussion (3h)

【教师简介】

Frank Elsner是德国亚琛工业大学教授、姑息医学诊所副主任、姑息治疗教育和培训咨询小组主席、教育委员会主席、姑息医学工作组主席、亚琛工业大学医学示范项目负责人，是德国姑息医学学会、德国疼痛学会、德中医学协会、欧洲姑息关怀协会、国际临终关怀与姑息治疗协会、德国麻醉医师等协会会员。他具有麻醉学、疼痛管理、姑息医学相关专业背景及研究、工作经历，于2006年获得亚琛工业大学医学系姑息医学专业的教授资格，这是德国首个姑息医学教授资格，现担任多个期刊审稿人。

皮雷特·帕尔（Piret Paal）是姑息治疗学教授。她目前担任奥地利萨尔茨堡帕拉塞尔苏斯医科大学姑息关怀研究所所长。她的研究兴趣包括以病人为中心的关怀、姑息关怀教育和精神关怀。她撰写或与他人合作撰写了大量经同行评审的文章、论文集、书籍等。帕尔博士教授自 2011 年以来一直是欧洲姑息关怀协会的成员。她是欧洲姑息关怀协会姑息关怀教育参考小组的活跃成员。

【Teacher Introduction】

Frank Elsner is a professor at RWTH Aachen University in Germany, serving as the deputy director of the Palliative Medicine Clinic, chairman of the Group Education and Training in Palliative Care, Chairman of the Education Commission, Chairman of the Palliative Medicine Working Group, and Head of Qualification Profiles (elective subjects) in the model program in medicine at RWTH Aachen University. He is a member of various professional associations, including the German Society for Palliative Medicine, the German Pain Society, the German-Chinese Society for Medicine, the European Association for Palliative Care, the International Association for Hospice and Palliative Care, and the Association of German Anaesthetists. With a background and expertise in anaesthesia, pain management, and palliative medicine, Elsner obtained the professorial qualification in palliative medicine from the Medical Faculty of RWTH Aachen University in 2006—the first such qualification awarded in Germany. He currently acts as a reviewer for several academic journals.

Piret Paal is a professor of palliative care. She currently works as the Director of the Institute of Palliative Care at Paracelsus Medical University in Salzburg, Austria. Her research interests include patient-centred care, palliative care education and spiritual care. She is the author and co-author of numerous peer-reviewed articles, scientific proceedings, books and book chapters. Prof. Dr. Paal has been a member of the European Association for Palliative Care since 2011. She is an active member of the EAPC’s Palliative Care Education Reference Group.